Malaria Genomics and Post-Genomics in LeidenAndy Waters, Taco Kooij, Marianna Karras, Shahid Khan
نویسندگان
چکیده
Genome structure of P. berghei and comparative genomics (Genome databases and bioinformatics) Introduction Genome structure of P. berghei GST and EST library at the University of Florida P. berghei sequencing project, Sanger Institute P. yoelii sequencing project, TIGR Comparative genomics in Leiden Genome conservation and synteny between rodent Plasmodium species Genome conservation and synteny between human, simian and rodent Plasmodium species The 48/45 multigene family: an extended and well-conserved gene family in Plasmodium The B9-locus: an example of conservation of a complex and gene dense locus Genes encoding variant (erythrocyte) surface antigens (VSA's): an example of species specificity References
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A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses.
Plasmodium berghei and Plasmodium chabaudi are widely used model malaria species. Comparison of their genomes, integrated with proteomic and microarray data, with the genomes of Plasmodium falciparum and Plasmodium yoelii revealed a conserved core of 4500 Plasmodium genes in the central regions of the 14 chromosomes and highlighted genes evolving rapidly because of stage-specific selective pres...
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